Goals from Brown Ideye, Kelechi Iheanacho and Odion Ighalo ensured Nigeria won their second straight game in four days.
A sparse crowd at the Stade Josy Barthel in Luxembourg City watched the Super Eagles take on the Luxembourg side for the first time at full senior level with Nigeria doing the early running.
Luxembourg did have a sight at goal early in the game but did not make hay as Nigeria dominated for majority of the first half.
Aminu Umar was a live-wire down the right for Nigeria as they pressed forward to get a goal. Kelechi Iheanacho had a chance to get Nigeria ahead but was denied by a well-timed tackle as Luxembourg goalkeeper Moris Anthony was kept busy.
Nigeria eventually got the first goal in the 35th minute of the game. A mazy run by Aminu Umar created a chance for Ogenyi Onazi whose shot was parried by Anthony but Brown Ideye was on hand to tap home his first international goal in three years.
The Super Eagles continued their dominance in the second half and were rewarded when Moses Simon capitalised on a poor clearance by the Luxembourg goalkeeper to square the ball to Kelechi Iheanacho to score his second goal in two matches to put Nigeria 2-0 up in the 68th minute.
Luxembourg thought they had clawed their way back into the game when Kenneth Omeruo’s mistake in defence gifted youngster Vincent Thill the opportunity to reduce the deficit in the 89th minute.
Odion Ighalo though sealed the game for Nigeria in added time to make it 3-1 and earn the Super Eagles a comfortable win.